Jean Claude Van Damme is an undercover agent called in for an assignment while on a family vacation. His family doesn't know what he does for a living, so he says he has a business emergency and goes off on what is supposed to be a quick trip. His mission is to pay a female thief some money and then get out of the country before anyone knows what has happened. In the midst of the exchange, soldiers rush in and the two go on the run. Their descriptions are broadcast on the news making it difficult for them to board the train.
It turns out the woman has stolen some vials containing small pox, and Mason, a villain that she used to work for, has taken over the train in order to get his hands on this biological weapon. When the vials break, droplets are spread via the train's duct work and those who were never vaccinated become ill. Also Jean Claude fights a lot of guys on a train, ala Steven Seagals Under Siege 2.
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